Filmography
| Role | Title | Year | Character |
|---|---|---|---|
| Actor | Interstellar | 2014 | Older Murph |
| Actor | The Age of Adaline | 2015 | Flemming |
| Actor | Requiem for a Dream | 2000 | Sara Goldfarb |
| Actor | The Exorcist | 1973 | Chris MacNeil |
| Actor | Pieces of a Woman | 2021 | Elizabeth Weiss |
| Actor | The Exorcist: Believer | 2023 | Chris MacNeil |
| Actor | Red Dragon | 2002 | Grandma Dolarhyde (Voice) |
| Actor | The First Lady (2022) | Sara Delano Roosevelt | |
| Actor | The Fountain | 2006 | Dr. Lillian Guzetti |
| Actor | Political Animals | Margaret Barrish | |
| Actor | Flowers in the Attic | 2014 | Olivia Foxworth |
| Actor | Dangerous | 2021 | |
| Actor | The Tale | 2018 | Nadine 'Nettie' Fox |
| Actor | The Wicker Man | 2006 | Sister Summersisle |
| Actor | Draft Day | 2014 | Barb Weaver |
| Actor | Petals on the Wind | 2014 | Olivia Foxworth |
| Actor | Three Months | 2022 | |
| Actor | Coma (2012) | Mrs. Emerson | |
| Actor | When a Man Loves a Woman | 1994 | Emily |
| Actor | Dying Young | 1991 | Mrs. O'Neil |
| Actor | According to Greta | 2009 | Katherine |
| Actor | The Baby-Sitters Club | 1995 | Emily Haberman |
| Actor | Ακολουθώντας την Καρδιά σου | 1995 | Hy Dodd |
| Actor | Flash | 1997 | Laura Strong |
| Actor | Playing by Heart | 1998 | Mildred |
| Actor | Divine Secrets of the Ya-Ya Sisterhood | 2002 | Viviane Joan 'Vivi' Abbott Walker |
| Actor | The Yards | 2000 | Val Handler |
| Actor | The Last Picture Show | 1971 | Lois Farrow |
| Actor | Alice Doesn't Live Here Anymore | 1974 | Alice Wyatt |
| Actor | Someday This Pain Will Be Useful to You | 2011 | Nanette |
| Actor | Queen Bees | 2021 | Helen Wilson |
| Actor | All I Wish | 2018 | Celia Berges |
| Actor | The Calling | 2014 | Emily Micallef |
| Actor | The House of Tomorrow | 2017 | Josephine Prendergast |
| Actor | W. | 2008 | Barbara Bush |
| Actor | The Loss of a Teardrop Diamond | 2008 | Miss Addie |
| Actor | Lucy in the Sky | 2019 | Nana Holbrook |
| Actor | Love, Marilyn | 2012 | Herself |
| Actor | The Velveteen Rabbit | 2009 | Swan |
| Actor | Mother, Couch! | 2024 | Mother |
| Actor | The Five People You Meet In Heaven | 2004 | Ruby |
| Actor | Deceiver | 1997 | Mook |
| Actor | Wiener-Dog | 2016 | Nana |
| Actor | Custody | 2016 | Beatrice Fisher |
| Actor | The Fear of God: 25 Years of The Exorcist | 1998 | Herself - 'Chris MacNeil' |
| Actor | Unity | 2015 | Herself - Narrator (voice) |
| Actor | Same Time, Next Year | 1978 | Doris |
| Actor | Wish You Well | 2013 | Louisa Mae Cardinal |
| Actor | The Book of Daniel | Beatrice Congreve | |
| Actor | The Mighty Macs | 2009 | Mother St. John |
| Actor | Nostalgia | 2018 | Helen Greer |
| Actor | Two Men in Town | 2014 | Mère Garnett |
| Actor | Mermaid | 2000 | Trish |
| Actor | About Scout | 2015 | Gram |
| Actor | The King of Marvin Gardens | 1972 | Sally |
| Actor | That's Life | ||
| Actor | Be Pretty and Shut Up! | 1981 | Herself |
| Actor | Surviving | 1985 | Tina Brogan |
| Actor | A Will of Their Own | Veronica Steward | |
| Actor | Easy Riders, Raging Bulls | 2003 | Herself |
| Actor | Act of Vengeance | 1986 | Margaret Yablonski |
| Actor | Harry and Tonto | 1974 | Shirley Mallard |
| Actor | The Spitfire Grill | 1996 | Hannah Ferguson |
| Actor | Providence | 1977 | Sonia Langham |
| Actor | The Cemetery Club | 1993 | Esther Moskowitz |
| Actor | Brush with Fate | 2003 | Rika |
| Actor | The Ellen Burstyn Show | Ellen Brewer | |
| Actor | And the Oscar Goes To... | 2014 | Herself - Interviewee |