Näitlejad

• Matty Finochio — Ted
• Seth Rogen
• Bryce Dallas Howard — Rachael
• Anjelica Huston — Diane Lerner
• Serge Houde — Richard Lerner
• Sarah Smyth — Jenny
• Peter Kelamis — Phil
• Daniel Bacon — Dr. Phillips
• P. Lynn Johnson — Bernie
• Veena Sood — Nurse Stewart
• Stephanie Belding — Friendly Nurse
• Stephen Colbert — Himself (archive footage)
• Joseph Gordon-Levitt — Adam Lerner
• Anna Kendrick — Katherine McKay
• Andrew Airlie — Dr. Ross
• Sugar Lyn Beard — Susan
• Matt Frewer — Mitch
• Philip Baker Hall — Alan
• Donna Yamamoto — Dr. Walderson
• Yee Jee Tso — Dr. Lee
• Jessica Parker Kennedy — Jackie
• Laura Bertram — Claire
• Marie Avgeropoulos — Allison
• Luisa d'Oliveira — Agabelle Loogenburgen
• Andrea Brooks — Attractive Woman #2
• Chilton Crane — Mother on the Bus
• Lauren Miller — Bodie
• Jason Vaisvila — Cute Guy with Dreads
• Brent Sheppard — Minister
• Ryan W. Smith — Joe
• William 'Big Sleeps' Stewart — George
• Amitai Marmorstein — Young Person on the Bus
• D.C. Douglas — Live Volcano Reporter (voice)