Näitlejad

• Emma Corrin — Cassandra Nova
• Ryan Reynolds — Wade Wilson / Deadpool
• Hugh Jackman — Logan / Wolverine
• Morena Baccarin — Vanessa
• Rob Delaney — Peter
• Leslie Uggams — Blind Al
• Karan Soni — Dopinder
• Matthew Macfadyen — Paradox
• Brianna Hildebrand — Negasonic Teenage Warhead
• Stefan Kapičić — Colossus
• Shioli Kutsuna — Yukio
• Randal Reeder — Buck
• Lewis Tan — Shatterstar
• Aaron Stanford — John Allerdyce / Pyro