Näitlejad

• Tom Riley — Leonardo Da Vinci
• Blake Ritson — Count Riario
• Alexander Siddig — Al-Rahim
• Elliot Cowan — Lorenzo Medici
• Laura Haddock — Lucrezia Donati
• Hera Hilmar — Vanessa Moschella
• Tom Bateman — Giuliano Medici
• Eros Vlahos — Niccolò Machiavelli
• Lara Pulver — Clarice Orsini
• James Faulkner — Pope Sixtus IV/Francesco & Alessandro della Rovere
• Gregg Chillin — Zoroaster da Peretola
• Carolina Guerra — Ima
• Jeany Spark — Ippolita
• Kieran Bew — Duke Alfonso
• Ray Fearon — Carlo de Medici
• David Schofield — Piero da Vinci
• Allan Corduner — Andrea Verrocchio
• Simone Lahbib — Laura Cereta
• Lee Boardman — Amerigo Vespucci.
• Matthew Marsh — Ferrante
• Paul Rhys — Vlad Țepeș
• Sabrina Bartlett — Sophia