Näyttelijät

• Juliette Binoche — Dr. Ouélet
• Anamaria Marinca — Dr. Dahlin
• Kaori Momoi — Motoko's mother
• Michael Wincott — Dr. Osmond
• Xavier Horan — Section Six Soldier
• Elisa Gabrielli — Loopers (voice)
• Scarlett Johansson — Major Mira Killian / Motoko Kusanagi
• Pilou Asbæk — Batou
• Michael Pitt — Kuze / Hideo
• Chin Han — Togusa
• Takeshi Kitano — Chief Daisuke Aramaki
• Peter Ferdinando — Cutter
• Rila Fukushima — Geisha robot
• Daniel Henshall — Skinny Man
• Christopher Obi — Ambassador Kiyoshi
• Tricky — Senior Monk
• Ike Amadi — Loopers (voice)
• Kirk Baily — Loopers (voice)
• Julianne Buescher — Loopers (voice)
• Artt Butler — Loopers (voice)
• David Chen — Loopers (voice)
• Paul Pape — Loopers (voice)
• Keith Silverstein — Loopers (voice)
• Scott Whyte — Loopers (voice)
• Lynnanne Zager — Loopers (voice)