Näyttelijät

• Tom Holland — Peter Parker / Spider-Man
• Michael Keaton — Adrian Toomes / Vulture
• Robert Downey Jr. — Tony Stark / Iron Man
• Marisa Tomei — May Parker
• Jon Favreau — Happy Hogan
• Gwyneth Paltrow — Pepper Potts
• Zendaya — Michelle
• Donald Glover — Aaron Davis
• Jacob Batalon — Ned
• Laura Harrier — Liz
• Tony Revolori — Flash
• Bokeem Woodbine — Herman Schultz / Shocker #2
• Tyne Daly — Anne Marie Hoag
• Abraham Attah — Abe
• Hannibal Buress — Coach Wilson
• Kenneth Choi — Principal Morita
• Selenis Leyva — Ms. Warren
• Angourie Rice — Betty
• Martin Starr — Mr. Harrington
• Garcelle Beauvais — Doris Toomes
• Michael Chernus — Phineas Mason / The Tinkerer
• Michael Mando — Mac Gargan
• Logan Marshall-Green — Jackson Brice / Shocker #1
• Jennifer Connelly — Karen / Suit Lady
• Gary Weeks — Agent Foster
• Christopher Berry — Randy
• Jorge Lendeborg Jr. — Jason
• Tunde Adebimpe — Mr. Cobbwell
• Tiffany Espensen — Cindy
• Isabella Amara — Sally
• Michael Barbieri — Charles
• Josie Totah — Seymour
• Hemky Madera — Mr. Delmar
• Zach Cherry — Street Vendor
• Kirk R. Thatcher — Punk on Street
• Yu Lew — Car Jacker
• Sondra James — Yelling Woman
• Bob Adrian — Yelling Man
• Gary Richardson — Day Sleeper
• Stan Lee — Gary
• Joe Hang — Thai Waiter
• Wayne Pére — History Teacher
• Chris Evans — Steve Rogers / Captain America
• Alexa Laraki — Tent Kid
• Liza Fagin — Tent Kid
• Kerry Condon — Friday
• John Penick — Mr. Hapgood
• Ethan Dizon — Tiny
• Amy Hill — Decathlon Moderator
• Miles Mussenden — Park Ranger
• Martha Kelly — Tour Guide
• Kevin LaRosa Jr. — Helicopter Pilot
• Ren Colley — Ferry Kid
• Jennifer Kim — Ferry Mom
• Ari Groover — Ferry Commuter
• Louis Gonzales — Ferry Commuter
• Stewart Steinberg — Ferry Commuter
• Andy Powers — Ferry Commuter
• Omar Capra — Yeah Spider-Man Guy
• Nitin Nohria — Dean Crimson
• Vince Foster — Stark Tower Technician
• Brian Schaeffer — Stark Tower Employee