Näyttelijät

• Kate Beckinsale — Selene
• Scott Speedman — Michael Corvin
• Michael Sheen — Lucian
• Shane Brolly — Kraven
• Erwin Leder — Singe
• Sophia Myles — Erika
• Wentworth Miller — Dr. Adam Lockwood
• Kevin Grevioux — Raze
• Todd Schneider — Trix
• Andreas Patton — Death Dealer Captain
• Danny McBride — Mason
• Kurt Carley — Werewolf
• Bill Nighy — Viktor
• Robbie Gee — Kahn
• Scott McElroy — Soren
• Brian Steele — Werewolf