שחקנים

• Andy Richter — Eugene Wilson
• Hal Sparks — School Fish #1 (voice)
• Kyla Pratt — Maya Dolittle
• John DiMaggio — Seeing Eye Dog / Wassup Fish / Mouse (voice)
• Denise Dowse — Secretary
• James Avery — Eldon
• Andy Dick — Lennie the Weasel (voice)
• Joey Lauren Adams — Squirrel (voice)
• Jamie Kennedy — Bandit / Forest Animal / Animal Groupie #1 (voice)
• Tom Kenny — Male Tortoise (voice)
• David L. Lander — Bird (voice)
• Michael McKean — Bird (voice)
• Kevin Pollak — Riley / Alligator
• Jeffrey Jones — Joe Potter
• Mark Griffin — Logger / Nature Show Narrator
• Lawrence Pressman — Governor of California
• Eddie Murphy — Dr. John Dolittle
• Kristen Wilson — Lisa Dolittle
• Mandy Moore — Girl Bear Cub (voice)
• David Cross — Dog / Animal Groupie #2 (voice)
• Georgia Engel — Giraffe (voice)
• Mike Epps — Sonny (voice)
• Cedric the Entertainer — Zoo Bear #1 (voice)
• Mandy Moore — Girl Bear Cub (voice)
• Frankie Muniz — Boy Bear Cub (voice)
• Bob Odenkirk — Animal Groupie #4 / Forest Animal / Dog (voice)
• Reni Santoni — Rat #2 (voice)
• Renée Taylor — Female Tortoise (voice)
• John Witherspoon — Zoo Bear #2 (voice)
• Lisa Kudrow — Ava (voice)
• Victor Raider-Wexler — Judge B. Duff
• Ken Hudson Campbell — Animal Control Officer / Dog / Animal Groupie #3 / Forest Animal (voice)
• Anne Stedman — Woman
• Tommy Bush — Farmer
• Adam Vernier — Farm Worker
• Shaun Robinson — Newscaster
• Googy Gress — Bear Announcer
• Lil' Zane — Eric
• Elayn J. Taylor — Eldon's Wife
• Raven-Symoné — Charisse Dolittle