출연진

• Will Smith — Robert Neville
• Steve Cirbus — Military Police
• Salli Richardson-Whitfield — Zoe Neville
• Reed Kelly — Infected
• Alice Braga — Anna Montez
• Charlie Tahan — Ethan
• Joanna Numata — Alpha Female
• Dash Mihok — Alpha Male
• Pat Fraley — President (voice)
• Mike Patton — Creatures (voice)
• Marin Ireland — Woman Evacuee
• John Grady — Infected
• James McCauley — Male Evacuee
• Deborah Collins — Civilian
• Caitlin McHugh — Special Blond Model
• April Grace — TV Personality
• Anthony Vincent — Infected
• Willow Smith — Marley Neville
• Alexander DiPersia — Male Evacuee
• Emma Thompson — Dr. Alice Krippin