출연진

• Danny Trejo — Machete Cortez
• Tom Savini — Osiris Amanpour
• Vanessa Hudgens — Cereza Desdemona
• Lady Gaga — La Camaleon
• Cuba Gooding Jr. — El Camaleon
• Marko Zaror — Zaror
• Billy Blair — Billy
• Electra Avellan — Nurse Mona
• Marci Madison — Nurse Fine
• Callie Hernandez — Space Babe
• Crystal Martinez — Wife of Mendez
• Elon Musk — Elon Musk
• Sofía Vergara — Madame Desdemona
• Walton Goggins — El Camaleon
• Mel Gibson — Luther Voz
• Demián Bichir — Mendez
• Amber Heard — Blanca Vasquez / Miss San Antonio
• Charlie Sheen — Mr. President
• Jessica Alba — Sartana Rivera
• Antonio Banderas — El Camaleon
• William Sadler — Sheriff Doakes
• Alexa PenaVega — KillJoy
• Julio Oscar Mechoso — Chepo
• Corey Burton — Trailer Voice Guy (voice)
• Bruce Campbell — Goon
• Michelle Rodriguez — Luz
• Elise Avellan — Nurse Lisa