출연진

• Lindsay Lohan — Cady Heron
• Rachel McAdams — Regina George
• Amanda Seyfried — Karen Smith
• Lacey Chabert — Gretchen Wieners
• Jonathan Bennett — Aaron Samuels
• Lizzy Caplan — Janis Ian
• Daniel Franzese — Damien Leigh
• Tina Fey
• Amy Poehler — June George
• Tim Meadows — Principal Ron Duvall
• Rajiv Surendra — Kevin Gnapoor
• Ana Gasteyer — Betsy Heron
• Neil Flynn — Chip Heron
• Daniel DeSanto — Jason
• Diego Klattenhoff — Shane Oman
• Alisha Morrison — Lea Edwards
• Julia Chantrey — Amber D'Alessio
• Dwayne Hill — Coach Carr
• Jonathan Malen — Kristen Hadley's Boyfriend
• Kristen Bone — Short Girl
• Tyson Fennell — Nfume
• Eve Crawford — English Teacher
• Stefanie Drummond — Bethany Byrd
• Sharron Matthews — Joan the Secretary
• Miranda Edwards — Michigan Girl
• Michelyn Emelle — Music Teacher
• Les Porter — Chemistry Teacher
• Jo Chim — Salesperson
• Jill Morrison — Crying Girl
• Jack Newman — History Teacher
• Ely Henry — Homeschooled Boy
• David Reale — Glenn Coco
• Dan Willmott — Mr. George
• Chris Anton — Huge Guy