Rollebesetning

• Keanu Reeves — John Constantine
• Rachel Weisz — Angela Dodson / Isabel Dodson
• Tilda Swinton — Gabriel
• Peter Stormare — Lucifer
• Shia LaBeouf — Chas Kramer
• Djimon Hounsou — Midnite
• Max Baker — Beeman
• Pruitt Taylor Vince — Father Hennessy
• Gavin Rossdale — Balthazar
• Josë Zúñiga — Detective Weiss
• April Grace — Dr. Leslie Archer
• Michelle Monaghan — Ellie
• Larry Cedar — Vermin Man
• Barbara Pilavin — Old Woman on Bus - Demon
• Laz Alonso — Williams