Rollebesetning

• Karla Sofía Gascón — Emilia Pérez / Juan "Manitas" Del Monte
• Selena Gomez — Jessi Del Monte
• Zoe Saldaña — Rita Moro Castro
• Edgar Ramírez — Gustavo Brun
• Adriana Paz — Epifanía
• Mark Ivanir — Dr. Wasserman
• Pablo Martinez — Narco-trafiquant
• Anabel Lopez — Berlinger's Secretary
• Stéphane Ly-Cuong — Male Surgeon
• Tulika Srivastava — Female Surgeon