Rollebesetning

• Daveigh Chase — Lilo
• Chris Sanders — Leroy
• Chris Sanders — Leroy
• Tia Carrere — Nani
• David Ogden Stiers — Jumba
• Kevin McDonald — Pleakley (voice)
• Zoe Caldwell — Grand Councilwoman (voice)
• Kevin Michael Richardson — Gantu
• Rob Paulsen — Reuben
• Debra Rogers — First Officer Ombit (voice)
• Jeff Bennett — Hamsterviel
• Tara Strong — Angel / Belle / Houdini / Pleakley's GACC Assistant (voice)
• Ving Rhames — Cobra Bubbles (voice)
• Liliana Mumy — Mertle Edmonds (voice)
• Frank Welker — Sparky / Sprout / Mr. Stenchy / Kixx / Hoilo / Slugger (voice)
• Nancy Cartwright — Shortstuff / Phantasmo (voice)
• Bobcat Goldthwait — Nosy (voice)
• Doug Stone — Ensign Getco (voice)
• Tress MacNeille — Bonnie / Poxy / Gigi / Topper / Felix / Melty / Amnesio / Cannonball / GACC Van Computer (voice)
• Jim Cummings — Heckler (voice) (uncredited)
• Jillian Henry — Elena (voice)
• Rocky McMurray — Clyde (voice)
• Lili Ishida — Yuki
• Kali Whitehurst — Teresa