Rollebesetning

• Michael J. Fox — Stuart Little (voice)
• Melanie Griffith — Margalo the Bird (voice)
• Nathan Lane — Snowbell (voice)
• Geena Davis — Mrs. Eleanor Little
• Hugh Laurie — Mr. Frederick Little
• Jonathan Lipnicki — George Little
• James Woods — The Evil Falcon (voice)
• Steve Zahn — Monty the Alley-Cat (voice)
• Maria Bamford — Teacher
• Rachael Harris — Additional Voices (voice)
• Marc John Jefferies — Will