Rollebesetning

• Amy Schumer — Amy Townsend
• Bill Hader — Dr. Aaron Conners
• Brie Larson — Kim Townsend
• John Cena — Steven
• Daniel Radcliffe — Dogwalker
• Colin Quinn — Gordon Townsend
• Tilda Swinton — Dianna
• LeBron James — LeBron James
• Mike Birbiglia — Tom
• Ezra Miller — Donald
• Marisa Tomei — The Dog Owner
• Randall Park — Bryson
• Pete Davidson — Dr. Conner's Patient
• Kyle Dunnigan — Kyle
• Amar'e Stoudemire — Himself
• Marv Albert — Himself
• Leslie Jones — Angry Subway Patron
• Kim Caramele — S'nuff Receptionist
• Josh Segarra — Staten Island Oli
• Nikki Glaser — Lisa
• Bridget Everett — Kat
• Claudia O'Doherty — Wendy
• Vanessa Bayer — Nikki
• Dave Attell — Noam
• Norman Lloyd — Norman
• Jon Glaser — Schultz
• Tim Meadows — Tim
• Matthew Broderick — Himself
• Method Man — Temembe
• Chris Evert — Chris Evert