Rollebesetning

• Kate Beckinsale — Anna Valerious
• Hugh Jackman — Van Helsing
• Richard Roxburgh — Count Vladislaus Dragulia aka Dracula
• David Wenham — Carl
• Will Kemp — Velkan
• Shuler Hensley — Frankenstein's Monster
• Kevin J. O'Connor — Igor
• Josie Maran — Marishka
• Silvia Colloca — Verona
• Elena Anaya — Aleera
• Tom Fisher — Top Hat
• Samuel West — Dr. Victor Frankenstein
• Alun Armstrong — Cardinal Jinette