Filmography
| Role | Title | Year | Character |
|---|---|---|---|
| Actor | Incredibles 2 | 2018 | Ambassador |
| Actor | Enemy | 2013 | Adam's Mother |
| Actor | The Beauty | Franny Forst | |
| Actor | Death Becomes Her | 1992 | Lisle von Rhoman |
| Actor | Joy | 2015 | Trudy |
| Actor | Conclave | 2024 | Sister Agnes |
| Actor | Spaceman | 2024 | Commissioner Tuma |
| Actor | Jurassic World: Chaos Theory | Nonna | |
| Actor | Domina | Balbina | |
| Actor | Blue Velvet | 1986 | Dorothy Vallens |
| Actor | Marcel the Shell with Shoes On | 2022 | Nana Connie |
| Actor | Shut Eye | Rita | |
| Actor | La Chimera | 2023 | Flora |
| Actor | Two Lovers | 2008 | Ruth |
| Actor | Vita and Virginia | 2019 | |
| Actor | Wild at Heart | 1990 | Perdita Durango |
| Actor | The Accidental Husband | 2008 | Greta Bollenbecker |
| Actor | The Solitude of Prime Numbers | 2010 | Adele |
| Actor | Merlin (1998) | Nimue | |
| Actor | Closet Monster | 2016 | Buffy |
| Actor | Napoleon (2002) | Joséphine de Beauharnais | |
| Actor | Problemista | 2023 | Narrator |
| Actor | The Odyssey (1997) | Athena | |
| Actor | Legend of Earthsea | High Priestess Thar | |
| Actor | Wyatt Earp | 1994 | Big Nose Kate |
| Actor | Master of Photography | Presenter | |
| Actor | Immortal Beloved | 1994 | Anna Marie Erdödy |
| Actor | Green Porno | Isabella Rossellini | |
| Actor | White Nights | 1985 | Darya Greenwood |
| Actor | Chicken with Plums | 2011 | Parvine |
| Actor | Big Night | 1996 | Gabriella |
| Actor | The Phantom | Dr. Bella Lithia | |
| Actor | The Architect | 2006 | Julia Waters |
| Actor | Infamous | 2006 | Marella Agnelli |
| Actor | The Dandelions | 2012 | Madame Trebla |
| Actor | Fearless | 1993 | Laura Klein |
| Actor | Empire | 2002 | La Colombiana |
| Actor | Roger Dodger | 2002 | Joyce |
| Actor | The Funeral | 1996 | Clara Tempio |
| Actor | Dark Eyes | 1987 | Claudia, Romano's daughter |
| Actor | Ingrid Bergman: In Her Own Words | 2015 | Herself |
| Actor | Cousins | 1989 | Maria Hardy |
| Actor | Isabella Rossellini's Green Porno Live | 2015 | |
| Writer | Isabella Rossellini's Green Porno Live | 2015 | |
| Actor | In the Pope's Eye | 1980 | Isabella |
| Actor | Don Quixote | 2000 | The Duchess |
| Actor | A Matter of Time | 1976 | Sister Pia |
| Actor | Seduce Me | Isabella Rossellini | |
| Actor | Helmut Newton: The Bad and the Beautiful | 2020 | Isabella Rossellini |
| Actor | Mammas | Isabella Rossellini | |
| Actor | Monte Walsh | 2003 | 'Countess' Martine |
| Actor | Infected | 2008 | Carla Plume |
| Actor | The Impostors | 1998 | The Veiled Queen |
| Actor | Late Bloomers | 2011 | Mary |
| Actor | Paolo Conte - Via con me | 2020 | Isabella Rossellini |
| Actor | The Innocent | 1993 | Maria |
| Actor | Land of Dreams | Jane | |
| Actor | About Face: Supermodels Then and Now | 2012 | Herself |
| Actor | Heights | 2005 | Liz |
| Actor | The Saddest Music in the World | 2003 | Lady Helen Port-Huntley |
| Actor | Blue Velvet Revisited | 2016 | Herself |