Obsada

• Owen Wilson — Lightning McQueen (voice)
• Larry the Cable Guy — Mater (voice)
• Michael Caine — Finn McMissile (voice)
• Emily Mortimer — Holley Shiftwell (voice)
• John Turturro — Francesco Bernoulli (voice)
• Thomas Kretschmann — Professor Z (voice)
• Eddie Izzard — Sir Miles Axlerod (voice)
• Guido Quaroni — Quido (voice)
• Tony Shalhoub — Luigi (voice)
• Peter Jacobson — Acer (voice)
• Joe Mantegna — Grem (voice)
• Bonnie Hunt — Sally Carrera (voice)
• Paul Dooley — Sarge (voice)
• Cheech Marin — Ramone (voice)
• Jenifer Lewis — Flo (voice)
• Lloyd Sherr — Fillmore / Combat Ship (voice)
• John Ratzenberger — Mack (voice)
• Michael Wallis — Sheriff (voice)
• Jeff Garlin — Otis (voice)
• Katherine Helmond — Lizzie (voice)
• Patrick Walker — Mel Dorado (voice)
• Franco Nero — Uncle Topolino (voice)
• Lewis Hamilton — Lewis Hamilton (voice)
• Jeff Gordon — Jeff Gorvette (voice)
• Jason Isaacs — Siddeley / Leland Turbo (voice)
• David Hobbs — David Hobbscap (voice)
• John Mainieri — J. Curby Gremlin (voice)
• Richard Kind — Van (voice)
• Brent Musburger — Brent Mustangburger (voice)
• Teresa Gallagher — Mater's Computer (voice)
• John Lasseter — Additional Voices (voice)
• Sig Hansen — Crabby (voice)
• Mark Winterbottom — Frosty (voice)
• Fernando Alonso — Fernando Alonso (voice)
• Jacques Villeneuve — Jacques Villeneuve (voice)
• Sebastian Vettel — Sebastian Vettel (voice)
• Stanley Townsend — Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice)
• Peter Jacobson — Acer (voice)
• Bruce Campbell — Rod "Torque" Redline (voice)
• Vanessa Redgrave — The Queen / Mama Topolino (voice)
• Velibor Topic — Alexander Hugo (voice)
• Edie McClurg — Minny (voice)