Obsada

• Jim Sturgess — Adam Ewing
• Ben Whishaw — Robert Frobisher
• Halle Berry — Luisa Rey
• Jim Broadbent — Timothy Cavendish
• Bae Doo-na — Sonmi-451
• Tom Hanks — Zachry
• Hugh Grant — Lloyd Hooks
• Hugo Weaving — Bill Smoke
• Susan Sarandon — Abbess
• James D'Arcy — Rufus Sixsmith
• Keith David — Joe Napier
• David Gyasi — Autua
• Zhou Xun — Yoona-939
• Robert Fyfe — Mr. Meeks
• Zhu Zhu — 12th Star Clone
• Martin Wuttke — Mr. Boerhaave / Guard / Leary the Healer
• Amanda Walker — Veronica
• Martin Docherty — Haskell Moore's Dinner Guest / Eddie Hoggins
• Shaun Lawton — Secretary
• Heike Hanold-Lynch — Ms. Judd Look-a-like
• Thomas Kügel — Vater
• Götz Otto — Groundsman Withers
• Alistair Petrie — Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman
• Sylvestra Le Touzel — Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership
• Andrew Havill — Mr. Hotchkiss
• Katy Karrenbauer