Obsada

• Matthew Laborteaux — Loop Group (voice)
• Kathleen Turner — Fraida
• Jim Carrey — Lloyd Christmas
• Jeff Daniels — Harry Dunne
• Brady Bluhm — Billy
• Steve Tom — Dr. Pinchelow
• Tembi Locke — Dr. Walcott
• Rachel Melvin — Penny
• Laurie Holden — Adele
• Rob Riggle — Travis / Captain Lippincott
• Don Lake — Dr. Meldman
• Patricia French — Ms. Sourpuss
• Paul Blackthorne — Emergency Room Doctor
• Eddie Shin — Gordy
• Atkins Estimond — Gus
• Tommy Snider — Tom
• Lindsay Ayliffe — Professor Garabedian
• Bill Murray — Ice Pick
• Grant James — Mr. Stainer
• Erin Allin O'Reilly — Asylum Nurse No. 1
• Josh Turner — KEN Convention Employee
• Carly Craig — Young Fraida
• Bryan Dilbeck — Dr. Dilbeck
• Dalton E. Gray — Young Harry
• Darien Johnson — KEN Convention Attendee
• Michael McCrudden — Audience Member
• Maia Moss-Fife — Receptionist
• June Shannon — Harry's Trailer Park Wife
• Julius Sharpe — KEN Conference Attendee
• Lex Lang — Loop Group (voice)
• Scott Menville — Loop Group (voice)
• Justin Shenkarow — Loop Group (voice)