Obsada

• Chris Pratt — Peter Quill / Star-Lord
• Zoe Saldaña — Gamora
• Dave Bautista — Drax
• Vin Diesel — Baby Groot
• Bradley Cooper — Rocket
• Michael Rooker — Yondu
• Karen Gillan — Nebula
• Pom Klementieff — Mantis
• Sylvester Stallone — Stakar Ogord
• Kurt Russell — Ego
• Elizabeth Debicki — Ayesha
• Chris Sullivan — Taserface
• Sean Gunn — Kraglin
• Tommy Flanagan — Tullk
• Laura Haddock — Meredith Quill
• Hannah Harlow — Sovereign Chambermaid
• Hilty Bowen — Sovereign Pilot
• Ben Browder — Sovereign Admiral
• Alex Klein — Zylak
• Luke Cook — Zylak's Frenemy
• Evan Jones — Retch
• Joe Fria — Oblo
• Terence Rosemore — Narblik
• Jimmy Urine — Halfnut
• Stephen Blackehart — Brahl
• Steve Agee — Gef
• Blondy Baruti — Huhtar
• Richard Christy — "Down There!"
• Rob Zombie — Unseen Ravager
• Sierra Love — Robot Courtesan
• Kendra Carelli — Robot Courtesan
• Milynn Sarley — Robot Courtesan
• Seth Green — Howard the Duck
• Molly C. Quinn — Howard's Date
• Michael Rosenbaum — Martinex
• Rhoda Griffis — Sneeper Madame
• Stan Lee
• David Hasselhoff — The Form of David Hasselhoff
• Mac Wells — Officer Fitzgibbon
• James Gunn Sr. — Weird Old Man
• Leota Gunn — Weird Old Man's Mistress
• Elizabeth Faith Ludlow — Easik Mother
• Wyatt Oleff — Young Peter Quill
• Gregg Henry — Grandpa Quill
• Damita Jane Howard — Grandpa Quill's Friend
• Ving Rhames — Charlie-27
• Michelle Yeoh — Aleta Ogord