Obsada

• Frank Welker — Scooby-Doo (voice)
• Will Forte — Shaggy Rogers (voice)
• Zac Efron — Fred Jones (voice)
• Amanda Seyfried — Daphne Blake (voice)
• Gina Rodriguez — Velma Dinkley (voice)
• Kiersey Clemons — Dee Dee Skyes (voice)
• Mark Wahlberg — Blue Falcon (voice)
• Ken Jeong — Dynomutt (voice)
• Jason Isaacs — Dick Dastardly (voice)
• Tracy Morgan — Captain Caveman (voice)
• Iain Armitage — Young Shaggy (voice)
• Mckenna Grace — Young Daphne (voice)
• Pierce Gagnon — Young Fred (voice)
• Billy West — Muttley (voice)
• Ariana Greenblatt — Young Velma (voice)
• Simon Cowell — Simon Cowell (voice)