Obsada

• Wentworth Miller — Michael J. Scofield
• Dominic Purcell — Lincoln Burrows
• Robert Knepper — Theodore "T-Bag" Bagwell
• Amaury Nolasco — Fernando Sucre
• Sarah Wayne Callies — Sara Tancredi
• Wade Williams — Bradley Bellick
• William Fichtner — Alexander "Alex" Mahone
• Paul Adelstein — Paul Kellerman
• Rockmond Dunbar — Benjamin Miles “C-Note” Franklin
• Jodi Lyn O'Keefe — Gretchen Morgan (Susan B. Anthony)
• Leon Russom — General Jonathan Krantz
• Marshall Allman — LJ Burrows
• Robin Tunney — Veronica Donovan
• Stacy Keach — Warden Henry Pope
• Michael Rapaport — Don Self
• Peter Stormare — John Abruzzi
• Danay Garcia — Sofia Lugo
• Robert Wisdom — Norman 'Lechero'
• Chris Vance — James Whistler
• Mark Feuerstein — Jacob Anton Ness
• Inbar Lavi — Sheba
• Augustus Prew — David 'Whip' Martin