Aktorët

• Will Smith — Agent Jay
• Tommy Lee Jones — Kevin Brown, Agent Kay
• Lara Flynn Boyle — Serleena
• Johnny Knoxville — Scrad/Charlie
• Tony Shalhoub — Jack Jeebs
• Patrick Warburton — Agent Tee
• Jack Kehler — Ben
• David Cross — Newton
• Michael Rivkin — the man with Harvey, the dog
• Howard Spiegel — New York guy
• Alpheus Merchant — MIB guard
• Jay Johnston — the younger Pizza Parlor MIB agent
• Joel McKinnon Miller — agent
• Rick Baker — MIB Passport Control Agent
• Martha Stewart — Martha Stewart
• Michael Jackson — Agent M
• Nick Cannon — MIB Autopsy Agent
• Doug Jones — Joey
• Biz Markie — Rapping Alien
• Linda Kim — Ambassador Lauranna
• Derek Mears — Mosh Tendrils
• Tim Blaney — Frank the Pug (voice)
• Sean Rouse — MIB Agent
• Peter Spruyt — MIB Customs Agent
• Kevin Cotteleer — MIB Customs Agent
• Tom Whitenight — MIB Agent C
• Martin Klebba — Family Child Alien
• Ernie Grunwald — Young Postal Employee
• Paige Brooks — 'Mysteries in History' Lauranna
• Barry Sonnenfeld — Neuralyzed Father
• Michael Garvey — Corn Face
• Michael Dahlen — Flesh Balls
• Kevin Grevioux — Pineal Eye
• Philip Goodwin — Diner Guy
• Greg Ballora — Sleeble (voice)
• Carl J. Johnson — Gleeble (voice)
• Thom Fountain — Neeble (voice)
• Brad Abrell — Mannix (voice)
• Mary Stein — Bird Lady Alien
• Denise Cheshire — Family Mom / Locker Alien
• Rip Torn — Zed
• Rosario Dawson — Laura Vasquez
• Peter Spellos — Captain Larry Bridgewater, The Motorman
• Michael Bailey Smith — Creepy
• Lenny Venito — New York guy
• Jeremy Howard — Bird Guy Alien / Postal Sorting Alien
• Peter Graves — Peter Graves
• Derek Cecil — Repairman Agent
• Marty Belafsky — MIB Customs Agent
• Richard Pearson — Gordy (voice)