Aktorët

• Johnny Depp — Rango (voice)
• Isla Fisher — Beans (Voice)
• Abigail Breslin — Priscilla (Voice)
• Ian Abercrombie — Ambrose (voice)
• Bill Nighy — Rattlesnake Jake (voice)
• Alfred Molina — Roadkill (Voice)
• Gil Birmingham — Wounded Bird (voice)
• Harry Dean Stanton — Balthazar (voice)
• Ned Beatty — Tortoise John (voice)
• Stephen Root — Doc / Merrimack / Mr. Snuggles (voice)
• Beth Grant — Bonnie (voice)
• George DelHoyo — Señor Flan - Mariachi Accordion (voice)
• Vincent Kartheiser — Ezekiel / Lasso Rodent (voice)
• Hemky Madera — Chorizo (voice)
• Alex Manugian — Spoons (voice)
• Joe Nunez — Rock-Eye (voice)
• Kym Whitley — Melonee (voice)
• Claudia Black — Angelique (voice)
• Timothy Olyphant — The Spirit of the West (voice)
• Ray Winstone — Bad Bill (voice)
• Blake Clark — Buford (voice)
• Keith Campbell — Sod Buster (voice)
• Patrika Darbo — Delilah / Maybelle (voice)
• Maile Flanagan — Lucky (voice)
• Charles Fleischer — Elbows (voice)
• Ryan Hurst — Jedidiah (voice)
• Lew Temple — Furgus / Hitch (voice)
• Alanna Ubach — Boo / Cletus / Fresca / Miss Daisy (voice)