Aktorët

• Bob Hoskins — Eddie Valiant
• Joanna Cassidy — Dolores
• Mel Blanc — Bugs Bunny / Daffy Duck / Tweety Bird
• Richard Williams — Droopy
• Richard LeParmentier — Lt. Santino
• Joel Silver — Raoul
• Christopher Lloyd — Judge Doom
• Charles Fleischer — Roger Rabbit / Benny The Cab / Greasy / Psycho
• Stubby Kaye — Marvin Acme
• Alan Tilvern — R.K. Maroon
• Lou Hirsch — Baby Herman
• Mae Questel — Betty Boop
• Frank Sinatra — Singing Sword
• Wayne Allwine — Mickey Mouse
• Frank Welker — Dumbo (voice)
• Nancy Cartwright — Dipped Shoe
• David L. Lander — Smartass
• June Foray — Lena Hyena / Wheezy
• Amy Irving — Jessica Rabbit (singing voice)
• Betsy Brantley — Jessica's Performance Model
• Jack Angel — Additional Voices