Aktorët

• Jeremy Irons — Rodrigo Borgia
• François Arnaud — Cesare Borgia
• Holliday Grainger — Lucrezia Borgia
• Derek Jacobi — Cardinal Orsini
• Lotte Verbeek — Giulia Farnese
• Colm Feore — Giuliano Della Rovere
• Emmanuelle Chriqui — Sancha of Aragon
• Joanne Whalley — Vanossa
• Ruta Gedmintas — Ursula Bonadeo
• David Oakes — Juan Borgia
• Aidan Alexander — Joffre Borgia
• Gina McKee — Caterina Sforza
• Michel Muller — Charles VIII
• Sean Harris — Micheletto Corella
• Ronan Vibert — Giovanni Sforza
• Steven Berkoff — Girolamo Savonarola
• Simon McBurney — Johannes Burchard
• Augustus Prew — Alfonso II of Naples
• Elyes Gabel — Djem
• Luke Pasqualino — Paolo
• Montserrat Lombard — Maria
• Peter Sullivan — Ascanio Sforza
• Julian Bleach — Niccolò Machiavelli
• Ivan Kaye — Ludovico Sforza