Aktorët

• Dominic West — Jimmy McNulty
• Wendell Pierce — Det. William 'Bunk' Moreland
• Sonja Sohn — Det. Shakima 'Kima' Greggs
• Clarke Peters — Detective Lester Freamon
• Michael K. Williams — Omar Little
• Deirdre Lovejoy — Rhonda Pearlman
• Wood Harris — Avon Barksdale
• Andre Royo — Bubbles
• Lance Reddick — Colonel Cedric Daniels
• Lawrence Gilliard Jr. — D'Angelo Barksdale
• John Doman — William A. Rawls
• Frankie Faison — Deputy Commissioner Ervin H. Burrell
• Chris Bauer — Frank Sobotka
• Aidan Gillen — Councilman Thomas 'Tommy' Carcetti
• Jim True-Frost — Roland "Prez" Pryzbylewski
• Idris Elba — Stringer Bell
• Domenick Lombardozzi — Thomas "Herc" Hauk
• Robert Wisdom — Howard 'Bunny' Colvin
• Amy Ryan — Officer Beatrice "Beadie" Russell
• Seth Gilliam — Sergeant Ellis Carver
• J.D. Williams — Preston 'Bodie' Broadus
• Corey Parker Robinson — Leander Sydnor
• Chad L. Coleman — Dennis "Cutty" Wise
• Jamie Hector — Marlo Stanfield
• Gbenga Akinnagbe — Chris Partlow
• Neal Huff — Chief of Staff Michael Steintorf
• Jermaine Crawford — Duquan "Dukie" Weems
• Tristan Mack Wilds — Michael Lee
• Isiah Whitlock Jr. — State Senator R. Clayton "Clay" Davis
• James Ransone — Chester 'Ziggy' Sobotka
• Bill Raymond — The Greek
• Charley Scalies — Thomas 'Horseface' Pakusa
• Pablo Schreiber — Nick Sobotka
• Chris Ashworth — Sergei "Serge" Malatov
• Delaney Williams — Sergeant Jay Landsman
• Brian Anthony Wilson — Detective Vernon Holley
• Gregory L. Williams — Detective Michael Crutchfield
• Robert F. Chew — Proposition Joe Stewart
• Method Man — Calvin "Cheese" Wagstaff
• Anwan Glover — Slim Charles
• Hassan Johnson — Roland "Wee-Bey" Brice
• Tom McCarthy — Scott Templeton
• David Costabile — Managing Editor Thomas Klebanow
• Julito McCullum — Namond Brice
• Maestro Harrell — Randy Wagstaff
• Michael B. Jordan — Wallace
• Christopher Mann — Councilman Anthony 'Tony' Gray