Rollista

• Annabelle Wallis — Madison Mitchell
• Maddie Hasson — Sydney Lake
• George Young — Kekoa Shaw
• Michole Briana White — Regina Moss
• Jake Abel — Derek Mitchell
• Jacqueline McKenzie — Dr. Florence Weaver
• Ingrid Bisu
• Jean Louisa Kelly — Jane Doe / Serena
• Susanna Thompson — Jeanne
• Christian Clemenson — Dr. Victor Fields
• Amir Aboulela — Dr. Gregory
• Mercedes Colón — Mendez
• Ruben Pla — Officer Rubin
• Jon Lee Brody — Officer Lee
• Paula Marshall — Beverly
• Zoë Bell — Scorpion
• Dan Ramos — Basco
• Shaunte Johnson — Beta
• Natalia Safran — Nurse Annie
• Mike Mendez — Hospital Security Guard #1
• Randy Haynie — Hospital Security Guard #2
• Cord Walker — Hospital Security Guard #3
• Jesus Trujillo — Research Doctor
• Lisa Catara — Research Orderly
• Danielle Nottingham — News Anchor
• Ray Chase — Gabriel (Voice)
• Marina Mazepa — Gabriel (Physical Performer)
• Mckenna Grace — Young Madison
• Madison Wolfe — Young Serena
• Andy Bean — Frank
• Patricia Velasquez — Nurse Velasquez