Rollista

• Roseanne Barr — Roseanne Conner
• John Goodman — Dan Conner
• Laurie Metcalf — Jackie Harris
• Sara Gilbert — Darlene Conner
• Lecy Goranson — Becky Conner
• Michael Fishman — DJ Conner
• Johnny Galecki — David Healy
• Estelle Parsons — Beverly Harris
• Glenn Quinn — Mark Healy
• Emma Kenney — Harris Conner
• Sarah Chalke — Becky II / Andrea
• Ames McNamara — Mark
• Jayden Rey — Mary
• Natalie West — Crystal Anderson-Conner