Besetzung

• Owen Wilson — Marmaduke (voice)
• Emma Stone — Mazie (voice)
• George Lopez — Carlos (voice)
• Christopher Mintz-Plasse — Giuseppe (voice)
• Steve Coogan — Raisin (voice)
• Fergie — Jezebel (voice)
• Kiefer Sutherland — Bosco (voice)
• Damon Wayans Jr. — Thunder (voice)
• Marlon Wayans — Lightning (voice)
• Sam Elliott — Chupadogra (voice)
• Lee Pace — Phil Winslow
• Judy Greer — Debbie Winslow
• Caroline Sunshine — Barbara Winslow
• David Walliams — Anton Harrison
• William H. Macy — Don Twombly
• Glenn McCuen — Bodie
• Heather Doerksen — Female Executive
• Ash Lee — Male Executive
• Christopher Attadia — Jock
• Jason Bryden — Man on Bench
• Raugi Yu — Drama Trainer
• Izaak Smith — Basketball Captain
• Keith Dallas — Emergency Road Worker
• P.J. Prinsloo — Lead Fireman
• Colin Decker — Fireman
• Garvin Cross — Fireman
• Chris Bradford — Fireman
• Hope Levy — Afghan #1 (voice)
• Devon Werkheiser — Drama Dog #1 / Shroom Dog #2 / Golden Dog / Cocker Spaniel (voice)
• Chris Colfer — Drama Dog #2 (voice)
• Hudson Thames — Delinquent Dog (voice)
• Todd Glass — Doberman / Shasta (voice)
• Ryan Devlin — Beach Dog #2 (voice)
• Jeffrey Garcia — Beach Dog #3 (voice)
• Liza Lapira — Party Dog #1 (voice)
• Jack McGee — Dalmatian (voice)
• Josh Gad — Bandana Dog (voice)