Reparto

• John Travolta — Bolt (voice)
• Susie Essman — Mittens (voice)
• Mark Walton — Rhino (voice)
• Malcolm McDowell — Dr. Calico (voice)
• Miley Cyrus — Penny (voice)
• James Lipton — The Director (voice)
• Nick Swardson — Blake (voice)
• Diedrich Bader — Veteran Cat (voice)
• J.P. Manoux — Tom (voice)
• Chloë Grace Moretz — Young Penny (voice)
• Ronn Moss — Dr. Forrester (voice)
• Greg Germann — The Agent (voice)
• Grey DeLisle — Penny's Mom (voice)
• Dan Fogelman — Billy (voice)
• Kari Wahlgren — Mindy Parker (voice)
• Randall Poffo — Thug (voice)
• June Christopher — (voice)
• Terri Douglas — (voice)
• Jackie Gonneau — (voice)
• Nathan Greno — (voice)
• Anne Lockhart — (voice)
• Scott Menville — (voice)
• Jonathan Nichols — (voice)
• Paul Pape — (voice)
• Pepper Sweeney — (voice)
• Phil LaMarr — (voice)
• David Cowgill — (voice)
• Tara Strong — (voice)
• Joe Whyte — (voice)
• Chris Williams — (voice)
• Kelly Hoover — Ester