Reparto

• Emmanuelle Vaugier — Jane Browning / Painkiller Jane
• Eric Dane — Nick
• Venus Terzo — Carla Browning
• Callum Keith Rennie — Mitchell
• Richard Roundtree — Colonel Watts
• Walker Howard — Blue
• Tate Donovan — Dr. Graham Knight / Lucas Insley
• Paula Brancati — Young Jane
• Elicia Mackenzie — Young Carla
• Martin Cummins — Sergeant Flynn
• Richard Harmon — Squeak