Elenco

• Ryan Reynolds — Detective Pikachu (voice)
• Justice Smith — Tim Goodman
• Kathryn Newton — Lucy
• Bill Nighy — Howard Clifford
• Ken Watanabe — Detective Yoshida
• Chris Geere — Roger Clifford
• Suki Waterhouse — Ms. Norman
• Josette Simon — Grams
• Rita Ora — Dr. Ann Laurent
• Karan Soni — Jack
• Max Fincham — Young Tim Goodman
• Simone Ashley — Girlfriend
• Diplo — DJ
• Omar Chaparro — Sebastian
• Ben Fox — Lead Cop
• Kadiff Kirwan — Mayor
• Ryoma Takeuchi — Male Pokémon Trainer
• Rina Hoshino — Mewtwo (voice)
• Kotaro Watanabe — Mewtwo (voice)
• Ikue Otani — Pikachu (voice)
• Rob Delaney
• Bern Collaço — CNM Reporter
• Jordan Long — Driver
• Bernardo Santos — RCPD Police Officer
• Matthew Cox — Passerby
• Priyanga Burford — Passenger