Elenco

• Lily Rabe — Claire Bennigan
• Barry Sloane — Wes Lawrence
• Milo Ventimiglia — Sean Bennigan/John Doe
• Kristen Connolly — Lena
• Derek Webster — Jessup Rollins
• Catalina Denis — Dr. Maria Benavidez
• Kylie Rogers — Minx Lawrence
• Kyle Harrison Breitkopf — Henry Bennigan
• Abby Ryder Fortson — Harper Weil
• Kayden Magnuson — Cassandra Winters
• Kristen Connolly — Lena
• Catalina Denis — Dr. Maria Benavidez
• David Andrews — Secretary of Defense Frommer / Secretary Frommer
• Martin Cummins — President Winters
• Teo Briones — Silas
• Dee Wallace — Willie Starling
• Alan Ruck — Executive Director Alex Myers
• Jamison Jones — Harrison Weil
• Maeve Dudley — Jane / 9 Year Old Girl
• Ona Grauer — Meg / Jane's Mother
• Tom Butler — Daniel Goetz
• Autumn Reeser — Amanda Weil
• Darien Provost — Nicholas Brewster
• Catherine Lough Haggquist — Renee
• Arien Boey — Freckled Boy Lucas
• Alison Araya — Callie
• Lauren K Robek — First Lady Winters
• John Billingsley — Ron Harcourt
• Terrell Ransom Jr. — Ethan
• Gwynyth Walsh — Dr. Tully
• Jay Paulson — Thomas Harcourt
• Michael St. John Smith — Air Force General
• Jeremy Guilbaut — Mr. Brewster
• Marc Senior — Field Tech
• Darien Sills-Evans — General Ousman Damba
• Adrian Hough — Dr. Rosen
• Steve Bacic — Reid
• Paul Jarrett — Justus
• Emma Tremblay — Tania
• Jay Brazeau — Rabbi Ezra
• Michelle Martin — News Reporter
• River Mather — 4-year-old Minx
• Lane Edwards — Press Secretary