Distribution

• Storm Reid — Meg Murry
• Levi Miller — Calvin O'Keefe
• Mindy Kaling — Mrs. Who
• Oprah Winfrey — Mrs. Which
• Gugu Mbatha-Raw — Dr. Kate Murry
• Rowan Blanchard — Veronica Kiley
• Bellamy Young — Camazotz Woman
• Daniel MacPherson — Calvin's Father
• Yvette Cason — Mrs. Teacher
• Zach Galifianakis — The Happy Medium
• David Oyelowo — The It (voice)
• Reese Witherspoon — Mrs. Whatsit
• Chris Pine — Dr. Alex Murry
• Conrad Roberts — Elegant Man
• Will McCormack — Mr. Teacher
• Oz Kalvan — Charles Wallace Double
• Isaac Ordonez — Charles Wallace Double