Elenco

• Ralph Fiennes — Prof. James Moriarty
• Hugh Laurie — Mycroft Holmes
• Rob Brydon — Inspector Lestrade
• Lauren Lapkus — Millie
• Noah Jupe — Doxy
• Bella Ramsey — Flotsam
• Jordan Long — Herbert
• Billy Jenkins — Mudfog
• Gerard Monaco — Officer
• Wolf Roth — Sigmund Freud
• Ethan Rouse — Newsreader
• Sonnyboy Skelton — Doxy's Dad
• Daniel Fearn — The Drooling Man
• Phil Hodges — Mr. Algernon Barkworth
• Paul Cassidy — Charlie Chaplin
• Benjamin Lok — Courtroom Person 3
• Jamie Baughan — Titanic Captain
• Bronson Webb — Jonathan Nightingale
• Steve Coogan — Gustav
• Will Ferrell — Sherlock Holmes
• John C. Reilly — Dr. John Watson
• Rebecca Hall — Dr. Grace Hart
• Pam Ferris — Queen Victoria
• Michael Culkin — Judge Over
• Kieran O'Brien — PC Smalls
• Oliver Maltman — Telegraph Operator
• Jason Thorpe — Butler
• Billy Zane — Himself
• Adam Scherr — Brawn