Cast

• Pierre Coffin
• Sandra Bullock — Scarlet Overkill (voice)
• Jon Hamm — Herb Overkill (voice)
• Michael Keaton — Walter Nelson (voice)
• Allison Janney — Madge Nelson (voice)
• Steve Coogan — Professor Flux / Tower Guard (voice)
• Jennifer Saunders — Reine Elizabeth II (voice)
• Geoffrey Rush — Narrator (voice)
• Steve Carell — Gru (voice)
• Katy Mixon — Tina (voice)
• Michael Beattie — VNC Announcer / Walter Jr. (voice)
• Hiroyuki Sanada — Sumo (voice)
• Paul Thornley — News Reporter (voice)
• Ava Acres — Additional Voices (voice)
• John Cygan — Additional Voices (voice)
• Brian T. Delaney — Additional Voices (voice)
• Bill Farmer — Additional Voices (voice)
• Keith Ferguson — Additional Voices (voice)
• Jess Harnell — Additional Voices (voice)
• Eve Karpf — Additional Voices (voice)
• John Kassir — Additional Voices (voice)
• Lewis Macleod — Additional Voices (voice)
• Mona Marshall — Additional Voices (voice)
• Gary Martin — Additional Voices (voice)
• Jan Rabson — Additional Voices (voice)
• Jim Ward — Additional Voices (voice)
• Colette Whitaker — Additional Voices (voice)
• Sherry Lynn — Additional Voices (voice)
• Carlos Alazraqui — Additional Voices (voice)
• Lori Alan — Additional Voices (voice)
• Bob Bergen — Additional Voices (voice)
• Jim Cummings — Additional Voices (voice)
• Danny Mann — Additional Voices (voice)
• Laraine Newman — Additional Voices (voice)
• Andy Nyman — Additional Voices (voice)
• Alexander Polinsky — Additional Voices (voice)
• Mindy Sterling — Additional Voices (voice)
• Tara Strong — Additional Voices (voice)