Cast

• Skyler Gisondo — James Griswold
• Ed Helms — Rusty Griswold
• Steele Stebbins — Kevin Griswold
• Christina Applegate — Debbie Griswold
• Beverly D'Angelo — Ellen Griswold
• Elizabeth Gillies — Heather
• Miles Doleac — Man on the Monument
• Nick Kroll — Colorado Cop
• Tim Heidecker — Utah Cop
• Kaitlin Olson — Arizona Cop
• Alkoya Brunson — Gary Peterson
• Hannah Davis — Ferrari Girl
• Ethan Maher — Boy on Plane
• R.F. Daley — Furious Husband
• Elizabeth Fendrick — Furious Wife
• Michael H. Cole — Male Guest
• Brooke Jaye Taylor — Female Guest
• Matthew Cornwell — Male Guest #2
• Cameron McIntyre — Young James (age 7 / 9)
• Chris Hemsworth — Stone Crandall
• Ron Livingston — Ethan
• Ryan Cartwright — Terry
• Regina Hall — Nancy Peterson
• Colin Hanks — Jake
• Leslie Mann — Audrey Griswold
• Chevy Chase — Clark Griswold
• Charlie Day — Chad
• Norman Reedus — Trucker
• Keegan-Michael Key — Jack Peterson
• David Clennon — Harry Co-Pilot
• John Francis Daley — Ride Operator
• E'myri Crutchfield — Sheila Peterson